Evercyte

Immortalized Human Somatic Cells

Highly differentiated human cells are of ever increasing importance as in vitro test systems in various fields of biomedicine, toxicology and biotechnology. Although normal somatic cells maintain a phenotype similar to the corresponding cells in vivo, the application of these cells is limited due to their finite life span. On the contrary, tumor cells can be grown without limitation but have lost essential characteristics.

In order to circumvent these limitations, Evercyte offers hTERT immortalized cell lines that are characterized by expression of cell-type specific markers and functions and thus are balanced in growth and differentiation. Besides sole expression of the catalytic subunit of human telomerase (hTERT), Evercyte has also developed protocols for combined introduction of hTERT and viral oncogenes or essential cell cycle regulators for life span extension without tumorigenic transformation of the cells. Derivatives of Evercyte cells (e.g. cell pellets, cDNA, RNA, extracellular vesicles) are available upon request.

Evercyte provides cells from following tissues

Colon                                                       

Cornea

Kidney                                                               

Lung                         

Mammary  Gland                                    

Muscle

Skin

Thymus

Vascular System