Evercyte

RPTEC/TERT1 & Podocytes

The kidneys play an essential role in the maintenance of body homeostasis by filtration of blood, reabsorption and secretion of molecules from or to urine. Among the cells that exert these functions are renal proximal tubular epithelial cells (RPTECs) and podocytes.

RPTEC/TERT1 – the only human renal proximal tubular epithelial cell line immortalized by telomerase alone, a widely accepted and published model cell line due to its unique primary cell like characteristics and functionalities.

PODO/TERT256 – the first hTERT immortalized human podocyte cell line on the market, characterized by expression of typical podocyte marker proteins.

There are also podocyte cell lines from other donors available!

Evercyte has established protocols for the isolation, growth and characterization of RPTECs and podocytes from kidney tissue biopsies as well as urine sediments.

Contact us for more information.

Applications:

  • Study of transport functions in the kidney
  • Assessment of in vitro nephrotoxicity
  • Use in phenotypic drug screening, orthogonal screening
  • Research on cilia function
  • Getting insights into kidney diseases and diabetes
  • Construction of bioartificial kidney tubule devices
  • Construction of lab-on-a-chip devices