Evercyte

Fibrobasts, Keratinocytes and Endothelial Cells

As an essential physiological barrier human skin plays important roles in e.g. the protection of the human body against pathogens, in heat regulation or evaporation control. Any perturbation of the skin becomes manifest in various diseases. In order to study processes such as inflammation, wound healing or tumor development human skin cells including fibroblasts and keratinocytes are important.

fHDF/TERT166 – hTERT immortalized human foreskin fibroblasts that are characterized by the ability to response to various cytokine stimuli similar to primary cells.

HDF/TERT164 - hTERT immortalized human adult skin fibroblasts that can be grown without limitations and show typical fibroblast characteristics

Application:

  • Study of extracellular matrix formation
  • Study of inflammation, wound healing, fibrosis and barrier function

 

NHEK/SVTERT3-5 – hTERT and SV40 early region immortalized human skin keratinocytes characterized by expression of typical marker proteins and the ability to differentiate towards functional 3D skin equivalents.

Cells from other donors are available upon request.

Application:

  • Performing of toxicological tests
  • Study of processes such as wound healing
  • Investigation of barrier functions and drug transport

 

HDMVEC/TERT164-B – hTERT immortalized human dermal lymphatic microvascular endothelial cells characterized by expression of cell-type specific marker proteins and in vitro differentiation capacity.

Applications:

  • Study of angiogenesis in disorders involving the lymphatic system such as wound healing or tumor lymphangiogenesis and tumor cell metastasis
  • Bioassays for testing the angiogenic properties of novel drugs